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Many Adverse Reactions Of Drug Treatment For Hyperthyroidism And Hypothyroidism – Don’t Wait Until You Have Problems Before You Regret It

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I believe that most patients with thyroid diseases are familiar with the two drugs Euthyrox and Sage. Whether they are hypothyroidism or hyperthyroidism, they cannot resist its energy, because too much thyroid hormone will not work, and too little will not work. , the reason for taking medicine is to balance the thyroid hormone in the body so that it is normal and not disordered. Over time, many patients with hyperthyroidism and hypothyroidism find that they can’t seem to get rid of these drugs.

However, the adverse reactions caused by these drugs are very common, and these adverse reactions often make patients deeply troubled!

1. Treat hyperthyroidism and skin allergies by taking Saitai for 20 days

I started to become allergic after taking the medicine for half a month, so I stopped taking the medicine for one day. I still feel the same after taking Raytadine. I itch unbearably every day like I have urticaria. The doctor said not to take a shower, not to blow dry, and not to lie down except when sleeping.

2. After taking Euthyrox for a month, my hair fell seriously.

I was only 19 years old and had just been diagnosed with hypothyroidism. I have been living a decadent life since then. The doctor prescribed Euthyrox and told me to take one tablet a day. As a result, my hair began to fall out, which was very serious. Ever since I got hypothyroidism, my friend said that I look like I have no energy all day long. I feel that my appearance has been seriously affected, and I have been afraid to look in the mirror since I became ugly.

3. Taking methimazole for half a year causes damage to liver function

After getting sick, I took methimazole for half a year. When I went for a review some time ago, I randomly checked my liver function. The doctor said that my liver function is now abnormal and my digestive system is seriously damaged. I have been prescribed a lot of liver-protecting medicines and I continue to take it.

The above are all typical adverse reactions of hormone drugs, because the reaction of each drug varies from person to person. Some people may have no symptoms while taking the medicine, while others may have more obvious symptoms. To this end, we have compiled a lot of information and drawn two notes on drug treatment for your reference.

(hyperthyroidism medication)

(hypothyroidism medication)

Although drugs can control indicators, we still have to remind everyone: everyone knows that drugs treat the symptoms but not the root cause, especially for patients with thyroid disease.

If the patient experiences some of the above-mentioned adverse reactions for a long time after taking the medicine for a period of time, it is recommended that the patient stop using the above medicine immediately and go to the hospital promptly to choose other treatment methods. Western medicine treatment cannot achieve a radical cure effect, and the dosage of medicine must be controlled at all times. If the dosage of medicine is not controlled well, you may often face the possibility of recurrence of hyperthyroidism and hypothyroidism.

Too Tired To Sleep! 10 Well-reviewed Games That Gamers Can’t Stop Loving

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Reviews have always been at the heart of the gaming world. Making or creating a new version of a game in a series based on the score it receives can be a straightforward topic, especially when some games don't behave the same as others. Get intense.

Such consensus is important not just for players, but for developers as well, as they often have clauses in their contracts requiring them to score a certain score on the game in order to receive additional rewards or be considered successful.

Having said that, one thing that has become increasingly apparent as time goes on is that critics and gamers are not on the same page.

Despite the amount of effort and discussion that goes into reviews, critics and fans are often at odds, resulting in a game that is well-received but actually hated by gamers.

The divide between these two camps will only grow, but some major titles will reflect this more than others, and critics aren't always right, as these games prove.

"Grand Theft Auto 4"

When GTA4 was released, it was immediately considered one of the most popular games of all time. Currently sitting at a whopping 98 on the Xbox 360 version, it's one of the most critically acclaimed games to date, setting up fans with some ridiculous expectations that, in hindsight, may never be realized.

However, players' low ratings aren't entirely due to the game not living up to their expectations, but rather the result of other installments in the series. GTA4 breaks away from its previous style in favor of a more measured and mature approach, with almost all functions and features designed to create a sense of realism in the world of Liberty City.

So while it was one of the best developed world games at the time, it wasn't very fun. The gunplay is too casual, the driving is too restrictive, and the narrative itself is too serious. As a result, this game is not a hit, and few people can really fall in love with it.

"Far Cry 2"

Although the game wasn't as well-received as its sequel, it managed to score an 85 when it was released in 2008.

The reason is simple: almost setting the standard for all open-world games, this series succeeds in creating a dynamic playground where players can do whatever they want in the game.

But unfortunately, the game also has some major sticking points – something that almost everyone who has played the sequel has experienced. First, the weapons you use in the game wear out quickly due to durability, which means you're always running around in combat, picking up another gun to take out enemies while you're riddled with bullets.

Add to that a malaria doctor who requires you to take regular doses of medicine, and enemies that make exploring the environment a chore, and it all makes for a frustrating experience that ultimately takes away from all the excitement. It was dragged into the sequel.

"Mass Effect 3"

There's no denying that the ending of Mass Effect 3 had a very negative impact on most players' opinions of the series as a whole, let alone the game itself. In the final minutes of the finale, the game reduces the trilogy's storyline to a few basic choices, a climax that seems to contradict many of the decisions players have made throughout the trilogy.

This was a source of frustration for fans at the time, who were disappointed that open, compelling side missions were used to repeat pickups in the same areas.

People believe that the development of this game was too hasty, which led to such a bad ending, and it is reasonable for it to be dissatisfied by players.

Destiny 2

The original Destiny didn't quite get the points it deserved like many expected in the weeks leading up to its release. Despite the many problems with the new game, no one expected that critics and players would react the same way as before, and maybe this time it will be unanimous.

Destiny 2, however, is a completely different story, with critics praising the game as a huge improvement over the original while players struggled to accept the shooting style they got.

While players have enjoyed this new sense of adventure and narrative cohesion, some still feel it's a letdown because it's not something fans know they can create.

At the same time, this game has also been accused of being "Destiny 1.5" rather than a true sequel. It has the same game rhythm as the first work, without adding any revolutionary changes, and it is not worth the three-year wait.

"DMC: Devil May Cry"

To some extent, DMC never even had a chance to really become popular with players. Since the game was announced, people have been met with relentless anger and ridicule for this "sequel" to the classic, and while fans' attitudes toward the game have changed somewhat, they still particularly dislike the "sequel" displayed by the protagonist. "Evil, charming and cruel" character.

They do have reason to be angry, because they abandoned the history of fighting games that have defined a distinct style, obviously in order to make this obviously "Japanese-style" game more attractive to mainstream American audiences.

But aside from that, it's still a fantastic game, and DMC's combat is as complex and rewarding as ever. At this time, you can also understand Sister Li why critics like it more than old fans, because it is still a better quality game.

"Dragon Age 2"

After the dual success of Mass Effect and Dragon Age: Origins, it managed to turn itself into one of the most popular developers in the world. Although they were later acquired by EA, they remained confident that the studio could continue to thrive at their creative peak no matter who their owners were.

Then "Dragon Age 2" came out.

This is a classic victim of a rush game that no longer adheres to the grand scale of the original game world, but instead switches to a more personal and restricted game world. Repeating battles and tasks in the same cities and dungeons, this RPG lacks diversity and imagination. The first part was obviously a sensation because of its grand scale, but now it is neglecting the basics.

Although this series was not enough to completely make players lose faith, it also made them cautious. For the studio, this also set a disastrous precedent for subsequent sequels.

"evolution"

Before Evolution was released, 2K had already started to build hype for the game.

However, with the release of Evolution, almost every player wants to tear this game to shreds. Microtransactions, pre-order bonuses, season passes and more, these concerns were confirmed on launch day.

It's not just that the game lacks substance, but the actual core gameplay itself isn't strong enough to appeal to any kind of player.

It's not fun to spend 10 minutes trying to find a monster hidden all over the map, and if you encounter stupid teammates, you may already be praying for the game to be over as soon as possible.

"Street Fighter 5"

After many years of following Street Fighter 4, a sequel finally came to PS4 and PC in 2016. Unfortunately, Capcom failed to learn from their fighting games, and Street Fighter 5 felt more like a start. rather than a finished product.

It would have been nice if this intention had been communicated properly before launch, but players have been waiting 8 years to get their hands on this new game, and now Capcom is telling them that they now have to wait not only for it to be done This game requires spending more money to get the full experience. . .

Fans wouldn't be interested in any fighting game without key features and systems, and the fifth installment in the series was met with critical aversion upon its first release, and even then, it was only Got a little bit of support.

"Call of Duty: Modern Warfare 3"

Almost every release of COD has been criticized by players, regardless of whether the game is actually any good, but in Modern Warfare 3, the criticism of the game is also justified.

While it ends the story in a relatively satisfying way, technical flaws and dull set pieces turn what should have been a thrilling ending into a mere footnote to previous Modern Warfare games.

Likewise, the multiplayer is probably the worst in the entire series, recycling weapons, perks, and gear from previous games without adding anything new. The map design is also very poor, resulting in a very poor combat experience for players.

A Customer Has An Adverse Reaction To Medication, What Should I Do?

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Recently, a customer went to a pharmacy to buy a certain traditional Chinese medicine suppository. After taking the medicine, he experienced adverse reactions such as local burning sensation. He came to the door, believing that there was a problem with the quality of the medicine and asked for a return. So, what is an adverse drug reaction? Is the occurrence of adverse reactions really a problem with the quality of the drug?

According to my country's "Adverse Drug Reaction Reporting and Monitoring Management Measures", adverse drug reactions (ADRs for short) refer to harmful reactions that occur under normal usage and dosage of qualified drugs and have nothing to do with the purpose of medication. The side effects we are usually familiar with are one kind of adverse reactions. In addition, adverse drug reactions also include toxic reactions, excessive effects, secondary reactions, first dose effects, sequelae, discontinuation syndrome, idiosyncratic reactions, Allergies and the "three causes" (carcinogenic, teratogenic, mutagenic), etc. are usually stated in the known adverse drug reaction instructions.

In daily life, people have different levels of understanding of adverse reactions. Some people become angry when talking about adverse reactions, some are indifferent, and some even think that the absence of adverse reactions means it is absolutely safe. In fact, these are all misunderstandings.

Whether the medication should be discontinued due to adverse reactions_whether the medication can be stopped due to adverse medication discontinuation reactions_whether the adverse medication discontinuation reactions affect the efficacy of the medication

Fewer adverse drug reactions ≠ safer drugs

It is not difficult to find that some drug instructions are very long and have a lot of adverse reactions, while some instructions are very short and the adverse reactions are either a few words or simply a few big words: not yet clear. This can easily lead to misunderstanding. It seems that the fewer side effects, the safer it is. Actually, this is not the case.

The import and marketing of drugs in my country must follow the adverse reaction reporting and monitoring system. For newly imported or marketed drugs, all adverse reactions must be reported within five years, and new and serious adverse reactions should be reported after five years. The unclear adverse reactions mean that they have not been discovered so far. Perhaps it has been on the market for a short time, perhaps because there are few statistical data, perhaps because the causes are too complex. In short, there are too many uncertain components, and the risk coefficient has not yet been determined. Therefore, we cannot think that drugs are safer based on this, and conversely, we cannot avoid treating diseases because of many adverse reactions.

Adverse drug reactions ≠ drug quality issues

whether the medication should be stopped due to adverse reactions_whether the adverse medication discontinuation reactions affect the efficacy of the medication_whether the medication can be discontinued due to adverse medication discontinuation reactions

According to the definition, there are three elements for adverse drug reactions: qualified drugs, normal usage and dosage, and harmful reactions unrelated to the purpose of medication. Here, the word "qualified" should be emphasized, which is a prerequisite for adverse drug reactions.

Of course, "a medicine is three parts poison", and the safety and risks of medicines are relative. Water can carry a boat, but it can also overturn it. Medicines have had dual properties since their birth. They can both cure and prevent diseases, but also have adverse reactions. It can be said that adverse reactions are innate and are the inherent risks and inherent attributes of drugs.

To be precise, any drug has adverse reactions, but the degree and frequency of occurrence are different. Medicines are not a panacea, and there is no medicine that has no adverse effects at all. In this sense, the presence of adverse reactions to a drug does not mean there is a quality problem.

poor medication Whether the drug can be stopped if the adverse reaction occurs_Whether the medication should be stopped due to the adverse reaction_Whether the adverse reaction will affect the efficacy of the drug

Adverse drug reaction ≠ adverse drug event

What we usually think of as harmful reactions caused by counterfeit and substandard drugs are, strictly speaking, called adverse drug events (ADE). Adverse drug events cover a wider scope than adverse reactions. In addition to adverse drug reactions, it also includes drug standards, quality defects, medication errors, drug abuse, etc. Compared with adverse reactions, adverse drug events have much greater human factors.

Adverse events caused by drug quality defects (fake and substandard drugs) are an infringement of patients' rights to life and health, which is strictly prohibited by law. As for adverse drug reactions, as long as the drug is qualified and the production, operation and user units conscientiously fulfill their obligations of notification, reporting and feedback, they cannot be considered to have intentional infringement. In other words, the harm caused by adverse reactions is not illegal.

In this case, if a customer has an adverse reaction when taking the medicine, can the pharmacy be exempted from liability? The answer is: it’s hard to get rid of it.

Medication_Whether adverse drug discontinuation reactions affect the efficacy of the drug_Can adverse drug discontinuation reactions allow the drug to be discontinued

First, it is difficult to determine the cause of adverse drug reactions. There are many reasons for adverse reactions. In addition to the reasons of the drug itself, there are also factors in the patient's body, as well as some situations where the mechanism of occurrence is not yet clear, which brings certain difficulties to actual operations. To take a step back, even if the pharmacy can prove its innocence, from the perspective of protecting the rights and interests of consumers, the competent authorities will not stand idly by.

Secondly, there is no legal basis for compensation for adverse drug reactions. At present, there are no express provisions in Chinese law regarding the identification and handling of disputes over adverse drug reactions. Theoretically, when an adverse reaction occurs to a drug, no party is at fault, but the harm to the patient is a fact. This also poses a problem in judicial practice. Regardless of the presumption of fault or the shared responsibility of all parties, it is unfair. Therefore, in order to balance the rights and interests of all parties, pharmacies as profit-making parties may also have to bear moral responsibilities.

In real life, for adverse reactions that are generally not serious, most pharmacies choose to make peace with the situation and compromise, either by returning or exchanging the product, or by making appropriate compensation. This is also a helpless move.

whether the medication should be stopped due to adverse reactions_whether the adverse medication discontinuation reactions affect the efficacy of the medication_whether the medication can be discontinued due to adverse medication discontinuation reactions

According to data from the National Adverse Reaction Monitoring Center, the National Adverse Reaction Monitoring Network received a total of 1.514 million reports in 2019, which must be said to be a huge number. In order to prevent the accumulation of feathers from forming into a boat and a group of people breaking their axis, liability identification for adverse drug reactions should be introduced as soon as possible. Some experts and scholars have called for the establishment of a relief and compensation mechanism for adverse drug reactions, such as the establishment of special insurance funds, hoping to make some useful explorations.

At the same time, the new "Drug Administration Law" has increased the number of subjects for reporting adverse drug reactions, and the reporting requirements have also changed to "report as soon as suspected." In addition, the recently announced "Regulations on the Administration of Drug Instructions and Labels" (revised draft) also plans to include "instructions that do not provide sufficient safety information and warning information" into the category of "counterfeit drugs". These are intended to force the whole society to take action through legislative means and pay attention to adverse drug reactions and medication safety.

From now on, adverse reactions that are “yet unclear” need to be carefully considered.

This article is original/organized by Chinese pharmacies.

How Did Prehistoric Humans Survive?Learn To Use Tools, Defeat Beasts, And Ultimately Win

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Survival game is the oldest game in human history. This is because prehistoric humans had to compete brutally with wild animals in order to survive. Prehistoric humans had to hunt for food. In order to survive, they had to act very carefully. In prehistoric times, humans were not at the top of the food chain. On the contrary, they may have been frequently preyed upon by large predators such as saber-toothed tigers, moas, and other terrifying prehistoric creatures. Prehistoric humans were in a brutal competition for survival in the wild with these beasts. , constantly hunting and being hunted with each other, and then gradually evolved to adapt to the harsh living environment, especially after learning to use tools, they finally defeated these beasts and finally won.

The living environment in prehistoric times was harsh and unforgiving for humans. Prehistoric humans faced many challenges, such as harsh weather conditions, scarce resources, and dangerous predators. They had to learn how to survive in this kind of environment by adapting to their surroundings. Survive in the environment. One of the biggest challenges facing humans at the time was finding enough food to survive and thrive. They relied primarily on hunting and gathering to find food, which meant they had to be skilled at tracking and hunting wild animals, as well as collecting fruits and other edible plants. To produce fruits, they must also be able to find clean water sources, which is often very difficult in harsh wild environments because water sources tend to be home to the largest number of predators.

Another challenge faced by humans at that time was the harsh weather conditions. They had to adapt to the extreme cold and heat in the environment. This often required them to make adequate clothing and shelter to protect themselves from the effects. This also meant that they had to learn how to Build a fire, which not only provides warmth but also allows them to cook food and ward off predators.

As we mentioned earlier, prehistoric humans were not at the top of the food chain. They were often preyed upon by large carnivores, for which they gradually learned how to outwit their opponents in order to survive. One of the ways humans were able to do this was through working together in groups. They would hunt together, using their intelligence and teamwork to take down large animals that they could not hunt alone. They would also share their resources, such as food and shelter. , which allows them to survive in harsh environments;

Another way is that they learned to develop weapons and tools, they used weapons like spears and arrows to hunt animals and tools like knives and axes to gather resources and build shelter, these weapons and tools made them more effective hunters and collector.

Prehistoric humans also evolved over time. In order to hunt and gather more efficiently, they gradually walked upright on two legs, which allowed them to walk longer distances. They also developed larger brains. , which enables them to think and reason more efficiently, and strengthens their ability to communicate and cooperate in groups, all of which enable them to share knowledge and resources more effectively.

In short, the survival game between prehistoric humans and beasts was a cruel competition that required the cooperation of wisdom and physical strength. The prehistoric living environment was also harsh and ruthless, but prehistoric humans adapted and survived by developing specialized characteristics and abilities. Learning how to cooperate in groups, develop weapons and tools, and communicate effectively laid a solid foundation for the future reproduction and growth of human groups.

Today, humans will continue to face more challenges, but our prehistoric ancestors have prepared us with all survival skills, including but not limited to learning from each other, communicating effectively, and thus adapting to the changing environment. I believe that through these we can To survive and develop better in our modern world, after all, we are much happier than our prehistoric ancestors, right?

The Blood Of The Guilty Dog

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"No Chi" (no Chi) is a Japanese animation adapted from Nitro+'s BL (male Xiang Danmei) game of the same name. Here is a detailed introduction to the animation:

The Blood of the Dog Game_The Blood of the Dog animation_The Blood of the Dog

The story takes place in a near-future world shrouded in crime and poverty. The protagonist Fuya Shibuya participates in a cruel gladiatorial competition in a city called "Fushiguro". The winner of the competition will receive the blood of a dog, a mysterious substance that can grant any wish.

The Blood of the Dog animation_The Blood of the Dog game_The Blood of the Dog

Fuya is a young man haunted by past events who hopes to find those who betrayed him by participating in gladiatorial tournaments. During the game, he met various opponents and friends, including the mysterious man Shaye and his friend Peak Season. As the game progresses, Fuye gradually uncovers the secrets behind Fushiguro Castle, and he also finds himself involved in a more dangerous conspiracy.

The Blood of the Dog Game_The Blood of the Dog animation_The Blood of the Dog

The animation of "Blood of the Dog" is famous for its dark, bloody and tense atmosphere. It shows a grim and harsh urban landscape, filled with violence and betrayal. The relationship between characters is also the focus of the animation, especially the emotional entanglement between the protagonist Fuye and his friends. At the same time, the animation also involves some supernatural and science fiction elements, adding a sense of mystery to the story.

The dog animation appears_The dog's blood is bloody

The animation of "Blood of the Blaming Dog" was broadcast from October to December 2010, with a total of 12 episodes. The director of this work is Keiichiro Kawaguchi, and the animation production is undertaken by A-1. While the anime received some attention when it aired, it also received some controversy for its depiction of gory violence.

The dog's blood is bloody_The dog's blood dog animation appears_The dog's blood game

Overall, "Blood of the Blaming Dog" is a deep and tense animation, suitable for viewers who like dark themes and delayed elements. It has a unique charm in showing the harsh environment of the city and the complex emotions of the characters, while also exploring themes of power, betrayal and justice.

There are 12 episodes in total. The current 12 episodes have been completed.

Improper Use Of Huoxiang Zhengqi Water Can Be Very Harmful To Health!

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Chief reporter Liu Yongsheng

Since the beginning of summer, the temperature has gradually increased, and the "wonderful effects" of Huoxiang Zhengqi Water are also spread on the Internet. It is said that Huoxiang Zhengqi Water can not only treat heatstroke, but also repel mosquitoes, and can also treat onychomycosis, athlete's foot, etc. These confusing statements indicate that people have a vague understanding of Huoxiang Zhengqi Water and do not pay enough attention to indications and medication safety issues. Pharmaceutical researchers suggest that the instructions for Huoxiang Zhengqi Water should include safety warnings such as "This product can cause anaphylactic shock and other serious allergic reactions" and "Children and people with allergies should use with caution."

Is Huoxiang Zhengqi Water a "panacea"?

The 80-year-old teacher Zhang saw a video on his mobile phone that taught people how to use Huoxiang Zhengqi water flexibly. The video says that Huoxiang Zhengqi Water has many wonderful uses in addition to treating heatstroke. For example, it can repel mosquitoes, treat onychomycosis and athlete's foot, dilute it in water for bathing children, and can also remove prickly heat.

Does Huoxiang Zhengqi Water really have so many uses? Is this safe? To answer this doubt, two questions should be clarified: first, what are the indications of Huoxiang Zhengqi Water, and second, what are the adverse reactions of Huoxiang Zhengqi Water.

Regarding this issue, a reporter from Dahe Health News interviewed Li Zhongyu, a surgical expert at Henan Provincial Hospital of Traditional Chinese Medicine. Li Zhongyu believes that the main function of this medicine is to relieve surface dampness, regulate qi and balance the central nervous system. It is an internal medicine and an oral medicine. With so many external treatment methods mentioned in the video, its efficacy is not credible.

Huoxiang Zhengqi Water has clear indications

Huoxiang Zhengqi Water is an over-the-counter drug, and "over-the-counter drug" is referred to as OTC. It refers to drugs that do not require a doctor's prescription and can be judged, purchased and used by consumers on their own. People can easily buy this drug from pharmacies, but if they do not pay attention to the indications, it can easily lead to abuse.

First let’s talk about the indications, that is, what diseases can Huoxiang Zhengqi Water treat? Li Zhongyu told reporters that Huoxiang Zhengqi Water is a traditional classic Chinese prescription that has the functions of relieving the surface and reducing dampness, regulating qi and harmonizing the body. Clinically, it is mainly used for colds caused by exogenous wind-cold, internal injury and dampness, or summer heat-dampness. The symptoms are mainly seen in severe headache, dizziness, chest and diaphragm tightness, epigastric and abdominal distension and pain, vomiting and diarrhea, gastrointestinal cold, etc.

Huoxiang Zhengqi Water is not suitable for the elderly, pregnant women, and infants

Real-life case: 80-year-old teacher Zhang told reporters that she experienced dizziness and discomfort after applying Huoxiang Zhengqi Water. She said: "It felt like being drunk."

The reporter went to the pharmacy to check and found out that common dosage forms sold over the counter include Huoxiang Zhengqi water (which is divided into alcoholic and non-alcoholic), Huoxiang Zhengqi dropping pills, Huoxiang Zhengqi capsules, etc. Several Chinese and Western medicine experts interviewed by the reporter repeatedly reminded that Huoxiang Zhengqi water containing alcohol should not be taken at the same time as cephalosporins and metronidazole drugs to avoid disulfiram-like reactions. The elderly, pregnant women, infants and young children are also not suitable to drink Huoxiang Zhengqi water.

Research example: A researcher analyzed 101 cases of adverse reactions. Perhaps we rarely see cases of adverse drug reactions of Huoxiang Zhengqi Water in daily life, but in clinical research, such cases are not uncommon.

Liu Songsong, a pharmaceutical researcher at Wuxi Fifth People's Hospital, collected 101 cases of adverse drug reactions of Huoxiang Zhengqi Water using literature analysis methods and made a detailed analysis. This result was published in "Chinese Pharmacovigilance" (2017 Issue 5 issues) magazine.

Abuse of this drug can cause serious consequences and may even lead to death.

According to reports, adverse drug reactions occur, involving multiple system organs, mainly including systemic damage, damage to the nervous and mental systems, damage to the cardiovascular system, damage to the skin and its appendages, damage to the digestive system, damage to the respiratory system, etc., among which systemic damage It accounts for the largest proportion, accounting for 28.30%.

According to reports, among the 101 cases of adverse reactions, 21 cases of serious adverse reactions occurred, mainly involving systemic damage, damage to the nervous and mental systems, and damage to the digestive and respiratory systems. Among them, systemic damage accounted for 67.50%. The main clinical manifestations were anaphylactic shock and disulfiram-like reaction. Another patient with suppurative vaginitis died due to incorrect medication route.

There are three things you should pay attention to when using Huoxiang Zhengqi Water:

1. Adverse drug reactions caused by incorrect dosage: The prescribed dosage of Huoxiang Zhengqi Water is 5 to 10 ml each time, taken orally twice a day. In the above-mentioned study cases, the oral dose reached 20 ml in 13 cases, far exceeding the prescribed dose. Among the 27 cases in children under the age of 14, 13 had medication exceeding adult doses.

2. Adverse drug reactions caused by incorrect medication routes: Patients who use bathing and intravenous drips have incorrect medication routes.

3. Adverse drug reactions caused by combined medication: According to case analysis, the combined use of Huoxiang Zhengqi Water with metronidazole, ceftriaxone sodium, furazolidone, cefoperazone sodium and other drugs can produce a disulfiram-like reaction, so Huoxiang Zhengqi Water should be avoided used in combination with these drugs.

Pharmacy experts suggest that safety warnings should be included in drug instructions

In order to prevent medication risks, Liu Songsong and other researchers suggested that drug instructions should be further improved. The medication information provided by the drug instructions is a direct and important way for patients to understand the drugs. It is recommended that the instructions for Huoxiang Zhengqi Water include safety warnings such as "This product can cause anaphylactic shock and other severe allergic reactions" and "Children and people with allergies should use with caution."

List Of Grading Lists Of 11 Common Adverse Reactions In Oncology

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Surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy are the main treatments for tumors. The adverse reactions caused by treatment cannot be ignored. Many adverse reactions are clinically fatal, so recognize them early, grade them according to their severity, and treat them as early as possible. The overall survival of cancer patients has been significantly improved.

The current classification of adverse reactions mainly refers to the fourth edition of CTCAE, which is divided into 5 levels:

Grade 1: Mild; asymptomatic or mild symptoms; only clinical or diagnostic findings; no treatment required.

Grade 2: Moderate; minor, local, or noninvasive treatment required; age-appropriate limitations in instrumental activities of daily living.

Grade 3: Serious or medically important but not immediately life-threatening; resulting in hospitalization or prolonged hospitalization; disability; limitation of independent activities of daily living.

Level 4: Life-threatening; emergency treatment required.

Level 5: Death related to AE.

Activities of Daily Living (ADL):

➤Instrumental activities of daily living include cooking, buying groceries or clothing, using the phone, managing money, etc.

➤Autonomous activities of daily living refer to washing, dressing and undressing, eating, going to the toilet, taking medicine, etc., and not being bedridden.

nervous system

Breathing, chest or mediastinum

digestive system

urinary system

blood and lymphatic system

Systemic

immune system

Musculoskeletal and connective tissue

Skin and subcutaneous tissue

infection and contagion

laboratory tests

references:

[1] U.S. Department of Health and Human Services. Common Adverse Reaction Time Evaluation Criteria Version 4.0

[2] Shi Yuankai, Sun Yan. Handbook of Clinical Oncology (Sixth Edition). [M]. People's Medical Publishing House. 2016: Appendix 1-6.

Triamcinolone Acetonide Acetate Injection

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ingredient report

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The ingredient of this product is triamcinolone acetonide acetate.

Chemical name: 16α,17-[(methylethylene)bis(oxy)]-11β,21-dihydroxy-9-fluoropregnanosteroid-1,4-diene-3,20-dione-21- acetate

Chemical Structure:

Molecular formula

Molecular weight 476.54

Anti-tuberculosis drugs and adverse reactions_The secret of adverse drug reactions of anti-tuberculosis drugs_What are the adverse drug anti-tuberculosis reactions

Excipients: hypromellose, sodium carboxymethylcellulose, polysorbate 80, benzyl alcohol, sodium chloride.

Character broadcast

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This product is a suspension of fine particles. The fine particles will sink after standing and become a uniform milky white suspension after shaking.

Indications broadcast

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Suitable for various skin diseases, allergic rhinitis, joint pain, bronchial asthma, frozen shoulder, tenosynovitis, synovitis, acute sprain, rheumatoid arthritis, etc.

Specification broadcast

What are the adverse drug anti-tuberculosis reactions_The secret of adverse drug reactions of anti-tuberculosis drugs_Anti-tuberculosis drugs and adverse reactions

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5ml:50mg

Usage and dosage report

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Intramuscular injection: 20 to 100 mg once a week;

Intra-articular or subcutaneous injection: usually 2.5 to 5 mg once.

Adverse reaction report

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What are the adverse drug anti-tuberculosis reactions What are the reactions_Anti-tuberculosis drugs and adverse reactions_What are the adverse reactions of anti-tuberculosis drugs

Glucocorticoids have no obvious adverse reactions when physiological dose replacement therapy is used. Adverse reactions mostly occur when pharmacological doses are used, and are closely related to the course of treatment, dosage, type of medication, usage and route of administration. Common adverse reactions include the following categories:

1. Long-term use may cause the following side effects: iatrogenic Cushing's syndrome, face and posture, weight gain, lower limb edema, purple lines, easy bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, bone Porosis and fractures (including vertebral compression fractures, pathological fractures of long bones), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth in children Suppression, glaucoma, cataracts, benign intracranial hypertension syndrome, impaired glucose tolerance and exacerbation of diabetes.

2. Patients may experience psychiatric symptoms: euphoria, agitation, delirium, restlessness, disorientation, and may also manifest as inhibition. Psychiatric symptoms are more likely to occur in people suffering from chronic wasting diseases and those who have had mental disorders in the past.

3. Concurrent infection is the main adverse reaction of adrenocorticoids. Mainly fungi, Mycobacterium tuberculosis, Staphylococcus aureus, Proteus, Pseudomonas aeruginosa and various herpes viruses.

4． Glucocorticoid withdrawal syndrome. Sometimes patients experience dizziness, fainting tendencies, abdominal or back pain, low-grade fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, and weakness after stopping the drug. After careful examination, if adrenal insufficiency and the original disease can be ruled out, If the disease relapses, it may be considered as a syndrome of dependence on glucocorticoids.

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It is prohibited for those who are allergic to this product and steroidal hormone drugs. Patients with the following diseases should generally not use it. In special cases, the pros and cons should be weighed before use, and attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer Disease, recent gastrointestinal anastomosis surgery, fractures, trauma repair period, corneal ulcers, hyperadrenocorticism, hypertension, diabetes, pregnant women, infections that cannot be controlled by antibiotics such as chickenpox, measles, fungal infections, and severe osteoporosis Disease, etc. This product contains benzyl alcohol and is prohibited for intramuscular injection in children.

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1. Induced infection: Under the influence of hormones, infections that have been controlled can become active. The most common case is the recurrence of tuberculosis infection. The application of hormones in certain infections can reduce tissue damage, reduce exudation, and alleviate the symptoms of infection and poisoning. However, it must be treated with effective antibiotics at the same time, and changes in the condition must be closely observed. After short-term use, the dosage should be quickly reduced and the medication should be discontinued.

2. Interference with diagnosis:

(1) Glucocorticoids can increase blood sugar, blood cholesterol, blood fatty acid, and blood sodium levels, and decrease blood calcium and blood potassium.

(2) The effects on peripheral blood include a decrease in the number of lymphocytes, eukaryotic cells, eosinophils and basophils, an increase in multinucleated leukocytes and platelets, and the latter may also decrease.

(3) Long-term use of large doses of glucocorticoids can cause false negative results in skin tests, such as tuberculin test, histoplasmin test and allergic reaction skin test.

(4) It can also reduce the thyroid 131I uptake rate, weaken the response of thyroid stimulating hormone (TSH) to TSH releasing hormone (TRH) stimulation, and make the TRH stimulation test results falsely positive. Interference with the results of the luteinizing hormone-releasing hormone (LHRH) stimulation test.

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(5) Make isotope brain and bone imaging weakened or sparse.

3. The following conditions should be used with caution: heart disease or acute heart failure, diabetes, diverticulitis, emotional instability and psychotic tendencies, systemic fungal infection, glaucoma, liver damage, ocular herpes simplex, hyperlipoproteinemia, hypertension , hypothyroidism (the effect of glucocorticoids is enhanced at this time), myasthenia gravis, osteoporosis, gastric ulcer, gastritis or esophagitis, renal damage or stones, tuberculosis, etc.

4． Follow-up examination: Those who use glucocorticoids for a long time should have the following items checked regularly:

(1) Blood glucose, urine glucose or glucose tolerance test, especially for those with diabetes or diabetic tendencies.

(2) Children's growth and development should be monitored regularly.

(3) Eye examination, pay attention to the occurrence of cataracts, glaucoma or eye infections.

(4) Serum electrolytes and fecal occult blood.

(5) Check for high blood pressure and osteoporosis, especially for the elderly.