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If You Love The Feeling Of Riding, Don’t Miss These Nine Motorcycle Games

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If you love the feeling of riding, don’t miss these nine motorcycle games | Leading Column · Game On

Touchle | 7 minutes ago

A motorcycle is not just a machine, it is the war horse of modern people. It witnessed the birth of Che Guevara and the death of Diana. It roars in the most violent way and leaps in front of you from behind the dunes, reflecting into the nightmare together with the flaming skeleton knight and the mechanical killer with red light dots flashing behind the sunglasses.

Although motorcycles have the highest accident fatality rate among all means of transportation, this still cannot stop people from being obsessed with them. In the vast lands of the United States and Australia, there are endless roads for riders to ride on. As a result, special organizations like the "Motorcycle Party" were born in these places.

This strange product that is nominally a formal motorcycle club, but also a mixture of gangster and fraternity attributes is so impressive that whenever we mention motorcycles, there will always be a bearded man in leather clothes and sunglasses behind it. The muscular man with the "Hells Angels" LOGO embroidered on it suddenly appeared in our minds.

But in fact, bikie culture is not synonymous with motorcycle culture.

Not long ago I traveled briefly in Europe. On the road between the golden wheat waves and the mountains, there will occasionally be sporadic motorcycle riders whizzing past. I once had a face-to-face encounter with them at a gas station.

Completely different from the image of "violent gangsters" in our imaginations, these leather-clad tough men in real life are just ordinary people. Some of their reasons for riding are to take their families on vacation, and others to go for a ride with their friends.

They will also stop at the rest area to buy cigarettes, choose a soft chanson CD, and finally hand the salesperson a kind smile.

The difference between them and ordinary people is that these guys who operate machinery have a love for motorcycles that ordinary people can't imagine. Generally speaking, this is a yearning for speed and freedom.

When I was a child, I used to sit in the back seat of my father’s Yamaha, burying my face in his broad back, dreaming that one day I could become a motorcycle rider. However, the good times did not last long. With the ban, my city, like 148 other cities across the country, said goodbye to motorcycles. Only occasionally in the middle of the night can you hear a few sigh-like howls.

We cannot simply judge whether the "motorcycle ban" is a policy that benefits the people, but it is certain that this patriarchal management has left many people with regrets. Fortunately, there are motorcycle games to make up for it.

Motorcycle games are the elders in the gaming field. From the arcade era to the current mobile game era, developers have created countless motorcycle-themed works. For example, the "Moto Racer" series produced by Ubisoft, the long-standing "Moto Racer" series on the PS platform, and "Moto Racer" which once served as the savior of many people's computer classes, etc.

However, this theme is not like the racing type, which can give the public an intuitive feeling in terms of vehicle specification changes, and bring a clear appearance modification and deployment process. The generation of this comparison result also has a lot to do with the strength of car culture.

On the other hand, whether it is racing or stunt motorcycle games, they all emphasize skills and it is difficult for players to get an intuitive driving pleasure. Most of the time, the games that really make us remember the pleasure of motorcycle driving are not They are works such as "GTA 5" or the "GTA 4" DLC "Lost and Cursed" that directly uses the speedsters as the protagonists in the game.

Beyond that, gameplay is also a factor. Racing games have so far derived from the original lap race into a variety of gameplay methods such as drag racing, drift racing, speed test points, and police and criminal role-playing tracking. However, the gameplay of motorcycle games is not that rich, and at least for domestic players Most players are not familiar with it.

In the field of mobile games, there are endless motorcycle-themed games in the App Store, but they are mixed. Below are the 9 motorcycle-themed mobile games I selected this week. I hope you can have some fun with them as I did.

1. "Tricycle: Frontline" (:) #iOS #

"" series has become a classic. Starting with a browser game in 2000, the studio has worked on dozens of games in this series over the past 15 years.

In 2013, they launched Trials: Frontline on mobile platforms. This work is a typical motorcycle stunt gameplay, and the performance is quite satisfactory. The game uses a horizontal screen, and the player controls the motorcycle to move forward and backward on the screen, as well as tilt forward and backward. This is also a common design for such games on mobile platforms.

The main feature of this game is the rich missions and upgrade system. Collecting and unlocking new cars and props is the player's goal in the game. In addition, the game also includes a story – of course, for a racing stunt game, this is just the icing on the cake.

The no-nonsense tutorial level at the beginning of this game left a deep impression on me. Players enter the game and go directly to the track. There are no teaching prompts for you to click, and you can play three levels in a row (until you are You can't escape the pit and die anyway), so at first I thought this game was just a short game with constant challenges.

As an aside, I really hope that all games can give players a certain degree of freedom at the beginning, allowing players to find their own fun, instead of teaching players to do everything like giving a child a pee.

Trials: Frontline is available for iOS 7.0+ and iPad and 4.0+ devices. Both the iOS version and the version are 88 MB, free with in-app purchases.

2. Bike Baron #iOS

The core gameplay of "Bike Duke" is basically the same as "Trials: Frontline". However, its graphics are more cartoon-like, the level design in the game is more dramatic, and special items such as explosive barrels are added. It's not challenging enough, but it's easy to get started and fun. If you are tired of the development content and boring plot in "Trials: Frontline", you might as well give it a try.

Bike Baron is suitable for iOS 5.1.1+ and iPad, with a size of 58.4 MB and a price of 12 yuan. There are in-app purchases.

3.《Trial 4》#iOS #

The " " series is an old stunt motorcycle game series on the mobile platform. So far, the fourth game has been released.

Compared with the previous two stunt motorcycle games, the graphics of this game are more realistic than that of "Tricycle: Frontline", and the game pace is also slower. It does not use a horizontal 2D screen, but chooses a 3D screen with a fixed viewing angle.

In addition to leaning forward and back to accelerate and decelerate, the game also includes a bouncing operation. Players can perform stunts in which people and vehicles separate in the air under certain circumstances to obtain higher scores.

Trial 4 is suitable for iOS 6.0+ and iPad and 4.0+ devices. The iOS version is 275 MB and the iOS version is 201 MB. It is free with in-app purchases.

4. "Crazy Time Travel" ( ) #iOS #

Pay attention to the points below

"Crazy Crossing" comes from GLU Company, a F2P motorcycle racing game. There is also a motorcycle stunt part in the game, but it mainly focuses on racing as the main game goal.

The biggest feature of this game is that it introduces the gameplay of music games into motorcycle racing. Players can make smooth turns or perform stunts by clicking on the flashing dots at the bottom of the screen at specific times.

We can also see this kind of thinking in the KOF music fighting game "King of Fighters Rhythm" and other works later launched by SNK, which is to apply a core gameplay suitable for mobile terminals to a game type that is not so suitable for mobile terminals. The graphics of this game are the best among the currently recommended games. Of course, its disadvantage is that it does not have much freedom of operation.

Crazy Time Travel is suitable for iOS 5.1+ and iPad and 2.1+ devices. The iOS version is 96.4 MB and the iOS version is 87 MB. It is free with in-app purchases.

5.《SBK 15》#iOS（US version）#

SBK is the abbreviation of "World Superbike Championship", which is a world-class motorcycle competition. The characteristic of this event is that the motorcycles selected by the contestants are not specially made, but commercially available mass-produced motorcycles with limited modifications.

The game "SBK" series is the official game of the SBK competition. It is one of the best motorcycle racing games on mobile platforms, both in terms of realism and professionalism. Players can use gravity sensing to control the direction of vehicles in the game, which is somewhat difficult to operate. For example, when cornering, the player must slow down and turn and find the correct cornering angle to pass smoothly.

SBK15 is suitable for iOS 6.1+ and iPad and 4.0.3+ devices. The iOS version is 322 MB. The size of the version varies depending on the device. It is free with in-app purchases.

6. "Ducati Challenge" ( ) #iOS #

Ducati () is a world-famous motorcycle team that has won the World Motorcycle Championship (Moto GP) many times. "Ducati Challenge" is a realistic motorcycle racing game launched by the Ducati team to promote the brand.

Because "Ducati Challenge" is an old game, the graphics are not as good as the latest "SBK 15", but the game has some more realistic settings. For example, when the wheels of a motorcycle run over the grass on the roadside, the wheels turn green.

Compared with the slight physical collision effect in "SBK", in "Ducati Challenge" the rider will really fly out if he hits the roadside. We can imagine that the reason why this kind of authentic design has not been adopted by new games is largely related to the acceptance of players.

Applicable to iOS 4.3+ and 2.3+ devices, the iOS version is 227 MB and costs 12 yuan; the size of the version varies by device and is free with in-app purchase.

7. "Hell Rider" () #iOS #

Before this, there had been a game called "A Game That Can Challenge Bird" by The Verge, "Snow Roll". In this game, players control a penguin stepping on a snowball, constantly adjusting its curves to avoid enemies along the way.

The basic gameplay of "Hell Rider" is the same as "Snowball", except that there are no longer penguins stepping on the snowballs in the game, but various Hell Riders (of course there are also little yellow ducks riding little sheep) passing through curves Come and crush all the skeletons.

The difficulty of the game is moderate and it is relatively easy to get started, but it is difficult to get high scores, especially when facing the BOSS battle at the end of each stage. For players, they need to find good opportunities to pick up bombs on the ground and throw them towards the opponent. The timing is difficult to grasp.

Suitable for iOS 6.0+ and iPad and 3.0+ devices, iOS version 50.9 MB, iOS version 40 MB, completely free.

8.《1.0》

"1.0" has a near-future cyberpunk-style story background, but in fact, this game is just another violent motorcycle gameplay. In the game, the player controls the motorcycle to speed along and kill the chasing opponents by sliding and slashing.

The game style is a highlight, but the overall performance of the game is not ideal. For example, the player can only move forward on a one-way lane, but the game is still set up as a two-lane lane, which makes the player's control of the character occupy an even smaller proportion in the game. . But the subject matter of this one makes it worth trying.

1.0 is suitable for iOS 7.0+ and iPad and 2.3+ devices. The iOS version is 41.5 MB and the iOS version is 34 MB. It is completely free.

9.《SXPD》#iOS #

"SXPD" is a near-future style game like the "1.0" introduced earlier, and it also has a distinctive style. The black-and-white game graphics make it look like a retro comic book, and in the most intense racing scene in the game, players can drive a motorcycle in a first-person perspective, which is not available in other games.

SXPD: Force is available for iOS 5.1+ and iPad and 4.1+ devices. The iOS version is 107 MB and costs 12 yuan; the iOS version is 85 MB and costs 1.99 US dollars.

10. Extra bonus: "Fix My Motorcycle" (Fix My: 3D) #iOS #

This bonus game isn't included in the recommendations for motorcycle games, but it's just as fun.

Modern people have forgotten how to deal with machinery. This was not the case in the past. At least in the 1950s, when you learn to drive, you also need to learn car maintenance – perhaps this is why another name for drivers is "chauffeur". So after recommending so many motorcycle driving games above, it’s time for us to learn how to repair motorcycles.

"Repair My Motorcycle" is a paid game priced at 12 yuan. This game uniquely chooses "Repair My Motorcycle" as the theme of the game. But relatively speaking, this game feels more like a secret room puzzle game to me, where players have to find various parts in a room. However, the actual disassembly part of the motorcycle in the game is relatively simple.

Suddenly I thought of a book called "Zen and the Art of Motorcycle Maintenance". Although it is difficult for us to experience Zen from this game, it is still possible to learn a little maintenance technology. After you get tired of racing at high speeds (and being thrown out of the car and slamming to the ground) and performing stunts, try repairing to experience another side of motorcycles.

Fix My is suitable for iOS 6.0+ and iPad and 2.3.3+ devices. The iOS version is 64.8 MB and costs 12 yuan; the iOS version is 72 MB and costs 1.99 US dollars.

The Most Complete Version Of "Descendants Of The Sun" In History. There Are All Versions Of Men, Women, Old And Young, Tall, Short, Fat And Thin.

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The most complete version of "Descendants of the Sun" in history. There are all versions of men, women, old and young, tall, short, fat and thin.

"Descendants of the Sun," South Korea's most popular TV series this year, has soared in ratings since its launch. Because this TV series is the first TV series in the history of KBS TV series that is fully produced before being broadcast, it is broadcast simultaneously on the Chinese online platform iQiyi while being broadcast in South Korea. As soon as the show aired, it immediately killed all men, women and children. Everyone was fascinated by Song Joong-ki and Oppa. Some even called him "my husband"! It has become a must-see TV series for those with good looks!

Let’s first review some classic scenes in the play

Classics are often easy to imitate, but difficult to surpass. This is not the case. Not long after the premiere of "Descendants of the Sun", various gods came to play classics. During the rehearsal of the music program "Music Bank", the Korean boy band JJCC dressed up as Song Joong-ki's Captain Liu and his colleagues in the play, posing with guns. One of them impersonated Song Hye-kyo, which was very funny.

Korean idols are on the move, so how can we in China be left behind? Subsequently, the Chinese men's running team also posted a series of photos of their names in the same military uniforms as Song Joong-ki: Taeyang's stewardess, Taeyang's robe, Taeyang's stepdad, etc. Baby even wrote, "Go with me when you are free on weekends." …?" This should be Brother Aite Xiaoming, can you tolerate this? Baby, you are already a wife, please restrain yourself!

There is also a Wenzhou hot mom who gave her children classic looks in the drama. Not to mention the two kids still look good. The cute version of Song Joong Ki and the cute version of Song Hye Kyo are so cute!

Similarly, "Descendants of the Sun" is also popular in Thailand. Thai netizens pranked Prime Minister Prayuth Chan-ocha by putting photos of Prime Minister Prayuth Chan-ocha together with those of Oppa Chung-ki. Of course, Prime Minister Prayuth Chan-ocha also praised the show very much!

Faced with Oppa's magical skills in seducing girls, the Thai girls couldn't calm down. Even the Thai soldier brother became a fan of the drama and even acted in it. The looks are still enough, but the heroine is not enough, so men come to join in. What is rhythm!

Faced with such a good-looking TV series, Vietnam couldn't stand it anymore. They even used "Descendants of the Sun" as the theme and took a set of wedding photos in the same seductive series of military uniforms as the original TV series. The bride was captured by a group of people in military uniforms. The men gathered around, with happy smiles on their faces, and the bride and groom also imitated various sweet scenes in the play. She has good looks and is so good at playing. She is the kind of person who would torture a single person to death!

By the way, this girl really got her "husband".

On the occasion of Qingming Festival, there was even a 50,000 Korean won ghost coin with Song Joong Ki’s portrait printed on it, which made people dumbfounded! Netizens said that it is simply outrageous! Some people also said, "It's very appropriate for the occasion. Isn't it just called a free chicken?" This incident was also complained by a large number of fans, "It's too much!", "It's so disrespectful!"

Faced with such a prank, the editor was also drunk! After reading these versions of "The Sun's…" from various countries, which one do you think is the strongest?

Detailed Explanation Of Anti-tumor Drug Classification And Mechanism Of Action

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1. Drugs that affect nucleic acid biosynthesis are cell cycle-specific drugs that mainly act in the S phase.

5-Fluorouracil (5-FU): Inhibits deoxythymidylate synthase and affects DNA synthesis. It can also be incorporated into RNA to interfere with protein synthesis. It is effective against a variety of tumors, especially digestive tract cancer and breast cancer.

6-Mercaptopurine (6-MP): Interferes with purine metabolism and hinders nucleic acid synthesis. It has good curative effect on acute lymphoblastic leukemia in children and is effective in treating villous epithelial carcinoma in large doses.

Methotrexate (MTX): Inhibits dihydrofolate reductase, prevents deoxythymidylate synthesis, and affects DNA synthesis. It can also prevent purine nucleotide synthesis and interfere with RNA and protein synthesis. For acute leukemia and chorioepithelial carcinoma in children.

Cytarabine (Ara-C): Inhibits DNA polymerase and prevents DNA synthesis. It can also be incorporated into DNA to interfere with its replication and cause cell death. It is an effective drug for the treatment of acute myeloid or monocytic leukemia in adults.

Hydroxyurea (HU): Inhibits ribonucleotide reductase and prevents DNA synthesis. Effective for chronic myelogenous leukemia and melanoma. Use with caution in patients with poor renal function.

2. Drugs that damage the structure and function of DNA are cell cycle non-specific drugs.

Such drugs include alkylating agents, antibiotics, and platinum-based preparations.

Alkylating agent: It has an active alkylating group, which can alkylate with certain groups of DNA or protein, form cross-links or cause depurination, causing DNA chain break; it can also cause nucleobase pairing errors, Causes damage to DNA structure and function.

1) Cyclophosphamide: Transforms into phosphoramide mustard in tumor cells, forms cross-links with DNA, and inhibits the growth and reproduction of tumor cells. It has a wide anti-tumor spectrum and is effective against malignant lymphoma, acute lymphoblastic leukemia, etc. It can also be used as an immunosuppressive drug. Its metabolite acrolein is excreted in the urine and irritates the bladder, which can cause chemical cystitis such as hematuria and proteinuria.

2) Thiotepa (TSPA): binds to the bases of DNA to inhibit tumor cell division. It has a broad anti-tumor spectrum and is used for breast cancer, ovarian cancer, liver cancer and malignant melanoma. Suppression of bone marrow.

3) Busulfan (Marylan): It acts as an alkylating agent after dissociation in the body. It has significant effect on chronic myelogenous leukemia. It can easily cause bone marrow suppression and occasionally pulmonary fibrosis.

4) Nitrosoureas: Highly fat-soluble and easy to penetrate the blood-brain barrier, they can treat brain tumors, melanoma, etc. Bone marrow suppression, gastrointestinal reactions, and occasionally liver and kidney toxicity are common. Carmustine, lomustine, and semustine belong to them.

antibiotics

1) Mitomycin C (MMC): cross-links with DNA double strands, inhibits DNA replication, or breaks part of the DNA. It has a broad anti-tumor spectrum and can be used with bleomycin and vincristine to treat cervical cancer; with doxorubicin and 5-FU to treat gastric cancer, lung cancer, chronic myelogenous leukemia, malignant lymphoma, etc. Can cause significant bone marrow suppression, gastrointestinal reactions, and occasionally cardiotoxicity.

2) Bleomycin (BLM): Binds to DNA at the adenine-thymine pairing to break DNA and prevent DNA replication. For squamous cell carcinoma, lymphoma, and testicular cancer. It can cause anaphylactic shock, and the most serious adverse reaction is pulmonary fibrosis.

metal compounds

Cisplatin (DDP) and carboplatin: Cisplatin can form cross-links with urapurine, adenine, and cytosine on DNA to damage the structure and function of DNA. It has a broad anti-tumor spectrum and is effective against testicular tumors, ovarian cancer, bladder cancer, breast cancer and other solid tumors. Can cause gastrointestinal reactions, bone marrow suppression, and hearing loss. The anticancer effect of carboplatin is similar to that of cisplatin, and its toxicity is lower, but it can still cause bone marrow suppression.

3. Drugs embedded in DNA that interfere with transcribed RNA are cell cycle non-specific drugs.

Actinomycin D: Intercalates between the DNA base pairs guanine and cytosine, hindering the function of RNA polymerase and preventing RNA synthesis. The anti-tumor spectrum is narrow, and it is effective against malignant hydatidiform mole, chorioepithelial carcinoma, lymphoma, nephroblastoma, rhabdomyosarcoma and neuroblastoma.

Daunorubicin: combines with DNA base pairs to prevent the transcription process, inhibit DNA replication and RNA synthesis, and treat acute lymphoblastic leukemia and acute myelogenous leukemia. It can suppress bone marrow and be highly toxic to the heart.

Doxorubicin (Adriamycin, ADM): Its mechanism of action is the same as that of daunorubicin, and it is a periodic non-specific drug. It has a broad anti-tumor spectrum; its adverse reactions are the same as those of erythromycin but with mild cardiotoxicity.

The anti-tumor mechanism of plicamycin is the same as that of daunorubicin, and it also has anti-parathyroid effects. It is used for testicular embryonal tumors and corrects hypercalcemia caused by cancer. Can cause nausea and vomiting, thrombocytopenia, granulocytopenia, liver and kidney toxicity.

4. Drugs that interfere with protein synthesis

Vinblastines: drugs that act on the M phase, mainly including vinblastine (VLB) and vincristine (VCR). They can interfere with spindle tubulin synthesis and halt cell mitosis in metaphase. VLB is mainly used for acute leukemia, malignant lymphoma and chorioepithelial carcinoma. It is also effective for lymphomas, but it has obvious bone marrow suppression. VCR has a good effect on pediatric acute lymphoblastic leukemia and is used in combination with other anti-cancer drugs to treat various cancers. VCR does not significantly suppress bone marrow and mainly causes neurological symptoms.

Podophyllotoxin and etoposide (VP16): Podophyllotoxin disrupts the formation of spindle fibers and inhibits mitosis. VP16 interferes with DNA topoisomerase II and breaks DNA. Clinically, it is often used in combination with cisplatin to treat testicular tumors and lung small cell carcinoma. Also used in lymphoma treatment. Can cause gastrointestinal reactions, bone marrow suppression, and liver toxicity.

Paclitaxel: Promotes tubulin polymerization and inhibits its decomposition, affects spindle function and inhibits tumor cell mitosis. It is suitable for metastatic ovarian cancer and is also effective for esophageal cancer and lung cancer. There is bone marrow suppression and peripheral neuropathy.

Harringtonine: Inhibits the initial stage of protein synthesis, decomposes ribosomes, releases new peptide chains, and inhibits mitosis. It has good effect on acute myeloid leukemia and is also effective on acute monocytic leukemia. Can cause myocardial damage.

L-asparaginase: It can hydrolyze serum asparagine, causing tumor cells to lack asparagine and inhibit their growth. Mainly used for acute lymphoblastic leukemia. Hypoalbuminemia and bleeding may occur.

5. Hormones do not have the adverse reactions of general anti-tumor drugs.

Adrenocortical hormone: inhibits lymphoid tissue and dissolves lymphocytes. It has good curative effect on acute lymphoblastic leukemia and malignant lymphoma. Also effective against chronic lymphocytic leukemia.

Estrogen: Reduces the secretion of interstitial cell hormones, thus reducing the secretion of androgens and causing anti-stimulant effects. For the treatment of prostate cancer. It is also used for breast cancer patients with visceral or soft tissue metastasis who are more than 7 years after menopause.

Androgens: It can inhibit the secretion of follicle-stimulating hormone and reduce the secretion of estrogen. It can resist the promotion of prolactin in breast cancer cells and fight breast cancer. It has a better effect on women with advanced breast cancer, especially bone metastases.

Tamoxifen: blocks the breast cancer-promoting effects of estrogen. Used to treat breast cancer.No androgenic side effects

Within 14 Days, 5 Games Announced Their Suspension Of Service. Is The 2D Market Becoming Impatient?

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These reasons for the bleak ending of the product deserve more thinking and vigilance from manufacturers.

June is the graduation season. As the college entrance examination bell rings and the defense speeches are given, batches of students will leave the familiar campus for the next stage of their lives. But for mobile game products, the announcement of cessation of operations, which is equivalent to "graduation", is the end of a product, which means that the product will no longer have a future.

The situation of the "graduation season" of mobile games in June 2022 seems to be even more tragic than in previous years. Counting from May 25, in just 14 days, five two-dimensional mobile games have announced the suspension of operations, many of which are products of NetEase and Bilibili.

It is said that "failure is the cornerstone of progress", so what lessons can these five consecutive "graduated" products bring us? And what signals will this continuous graduation reflect in the market. These are the focus of this article.

01 Short-term pain, what’s wrong with games that graduate in less than a year?

If I were to group these five games, I would divide them into the long pain group and the short pain group.

Needless to say, the short-term pain group is a product that has been online for a relatively short time.

"Dream Walk" is a two-dimensional card turn-based mobile game developed by Time and represented by Bilibili. The product was launched on January 12, 2022, and graduated from the market in just half a year.

If you only evaluate this game from the perspective of "what's there", you will find that this is really not a bad game. The characters have L2D three-dimensional drawing and 3D modeling, mature turn-based combat and development system, and interesting game plot, which made this game popular among a group of players when the game was first launched.

(But to be fair, the level of vertical painting in "Picking Light and Dreaming" is actually average)

Perhaps due to funding issues or operational planning issues, the R&D team failed to update the game content efficiently after the game was officially launched. As a result, the player base and game revenue dropped again and again, causing the game to almost completely lose the market. Competitiveness.

("Picking Light and Dreaming" Ios best-selling ranking)

Such a product flow naturally makes "Shining Dream Journey" one of the few products to graduate within half a year.

"Luna's Labyrinth" is a two-dimensional card mobile game owned by NetEase. This product will launch public beta on July 27, 2021.

Compared with ordinary card mobile games, "Labyrinth of the Moon" has many highlights in product design, such as adding meat pigeon gameplay to the game, NetEase's outstanding character art, and a battle system similar to "Princess Connect" The frame makes this product look good.

The slogan of giving away 200 draws in the open beta of the game is a powerful medicine, which has doubled the expectations of many players who want to have fun in the game card pool.

As a result, when the game was officially launched, players discovered that the so-called 200 draws actually meant that players could reset the result of 10 consecutive draws 200 times. Players who felt cheated naturally chose to stay away from the game and dropped the game's rating to about 5 points (out of 10 points). The 200-draw event at the launch of the server has embarrassed the player base of "Labyrinth of the Moon" since its launch, and caused the game to announce the cessation of operations in less than a year.

"Empty Box Humanoid" is also a 3D action IP mobile game released by Bilibili. The IP of the game comes from the animation project "-The Girl Without a Heartbeat". This product will be launched on July 8, 2021.

To be fair, the 3D action system of "Empty Box Humanoid" has a certain design, but this design has no highlights in 2021. Instead, some players have criticized the combat system for being cumbersome to operate.

Regardless of the game's combat system, in fact, the character 3D models, battle scene construction, and character drawings of this game are not particularly competitive in the two-dimensional action game market in the past two years.

The less competitive game content and the relatively low popularity of the game IP in mainland China eventually led to a sharp drop in the game's revenue and the operator quickly terminated the operation.

02 Long-term pain, games that have struggled for several years and still come to an end

Although the products in the long-term pain group did not end hastily when the operation period was less than a year, they could not escape the fate of a dismal ending. Compared with the relatively clear "reasons for graduation" of the products in the short-term pain group, the products in the long-term pain group will be discontinued due to various factors.

"Twin Vision" is a top-down shooting game developed by the Girl Coffee Gun production team and represented by Bilibili Games. The product was launched on November 19, 2019.

The foundation of "Twin Horizons" is actually the best among these 5 games. It has a player base inherited from the previous games with the same IP. The distinctive top-down shooting gameplay and good game art in 2019 have given this game a good player base. This is a point that many players are not satisfied with since the game stopped updating. This can also be seen in She's speech.

But unfortunately, due to the combination of factors such as the decline in gameplay competitiveness over time, the epidemic interfering with the productivity of the R&D team, and extremely low product promotion, this former star was terminated due to deteriorating sales. symbol.

Out of love for the product, the R&D team still announced the next main chapter of the game and the launch time of the card pool in the announcement, which can be regarded as a decent curtain call for this product and the IP behind it that has lasted for several years.

"Shougen no Soul – Fantasy Cuisine" can be said to be a truly "long and painful" character in the long-term pain group, because this product, with a development cycle of more than 2 years, issued an announcement to cease operations before it was even launched.

It can be seen from the title that the IP of this game comes from the popular animation IP "Spirit of the Shokhalberd". The popularity of this IP still has a certain appeal in mainland China. If it is developed properly, "Shoji no Soul – Fantasy Cuisine" should be a product with good results.

However, Shanghai Wapu Network, which is responsible for its research and development, unexpectedly chose the match-3 gameplay as the core gameplay of the game. Such an alternative gameplay naturally makes many "Spirit of the Halberd" IP audiences not very interested in this product since the game's internal beta stage.

If we say that Shanghai Wapu Network’s choice of match-3 gameplay is a random choice, it would be a bit unfair to them. In the Japanese market, there are a certain number of two-dimensional IP mobile games that choose match-3 gameplay, and most of them can survive their first anniversary safely.

(The IP-adapted mobile game of "Fifth Quarter Flower Marriage" is a match-3 gameplay. It has been successfully operating for more than a year with a mixed monetization model of paid card drawing and paid props obtained by watching advertisements.)

But in the domestic environment, the match-3 gameplay is obviously not a good target for domestic two-dimensional players in recent years. Therefore, the positioning error in the initial stage ultimately ruined this R&D project that actually had some ideas.

(The product’s low ratings and reservations are obviously not good enough for a product that has been developed for more than two years)

Of course, some players have reported that copyright issues may have contributed to the discontinuation of this product.

03 Conclusion

The reasons why the five products were discontinued are different, and they bring us different thoughts. As the development time and labor costs of an excellent product continue to rise, developers must be more thoughtful and vigilant about the reasons for the demise of the product to avoid years of team efforts due to some unreasonable operations. The irreversible impact of the

In addition to the respective reasons for each product's curtain call, the epidemic and the general environment of the version number are also the common reasons for the hasty curtain call of this batch of products.

As shown above, 4 of these 5 products are products from powerful manufacturers such as Bilibili Games and NetEase, but most of them have ceased operations in a relatively short period of time. This once again proves that the current market environment has put certain pressure on some large and medium-sized manufacturers.

This makes them less patient about the long-term performance of their products. The specific manifestations of this impatience are not only the rapid termination of product operation, but also the rapid termination of product resource investment. If you take a closer look at the several games that will be discontinued, you will find that most of them have not updated new substantial content for several months, and do not have good push resources.

From the manufacturer's point of view, this is a natural move to stop losses, but it also completely ruins the R&D team's opportunity to save the product. Perhaps in the future, there will be fewer and fewer stories about product operations that start low and move high, because some large and medium-sized manufacturers no longer have the patience to wait.

As various large and medium-sized manufacturers begin to integrate more efficiently and even cut off their own product resources, the era of large-scale reserve and launch of products in the past is one step closer to withdrawing from the stage of history. The bright future will also be further away from small and medium-sized teams and manufacturers with weak strength.

PD-1 Immunotherapy, Adverse Reactions And Grades In Chinese Cancer Patients

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Tumor issues, private message on WeChat for free

Immune checkpoint inhibitors, represented by PD-1, play an important role in tumor treatment. By mobilizing the human immune system to kill tumors, patients are expected to achieve a longer survival period.

But there is a flip side to any drug – treatment-related adverse effects. So, what adverse reactions are likely to occur in Chinese cancer patients when treated with PD-1, and what are their levels?

1. Pay attention to adverse reactions when looking forward to treatment results

First, let’s introduce two concepts: treatment-related adverse events (TRAE) and immune-related adverse events (irAE). The range of TRAE is much larger than that of irAE.

l TRAE: It is an adverse reaction that occurs during treatment. It may or may not be caused by PD-1.

l irAE: It is the main treatment-related adverse reaction of immune checkpoint inhibitor PD-1. The possible reason is the autoreaction caused by immune checkpoint inhibitor.

A recently published document systematically summarizes these adverse events in Chinese patients using immunotherapy.

A summary analysis of 13 clinical trials covering 1,063 tumor patients was conducted, of which 922 patients were treated with immune checkpoint inhibitor monotherapy, accounting for 86.7%. There are 141 tumor patients using combination therapy, that is, PD-1 combined with chemotherapy, or PD-1 combined with anti-angiogenesis targeted drug therapy, and the proportion of patients treated with combination therapy is 13.3%.

As shown in the figure below: the probabilities of any grade of treatment-related adverse reactions, grade 1-2 treatment-related adverse reactions, and grade 3-5 treatment-related adverse reactions in these patients were 84.1%, 63.3%, and 20.9% respectively. The probability of immune-related adverse reactions (irAE) of any grade, grade 1-2, and grade 3-5 were 43.3%, 40%, and 3% respectively.

Figure 1 Probability of treatment-related adverse reactions and immunotherapy-related adverse reactions

44 patients discontinued medication due to adverse reactions, accounting for 4.3%. Eight patients died due to treatment-related adverse effects.

The grade 3-5 treatment-related adverse reactions (TRAE) and immune-related adverse reactions (irAE) of immune checkpoint inhibitors alone were: 17% and 2% respectively; while the grade 3-5 treatment-related adverse reactions of combination therapy were (TRAE) and immune-related adverse reactions (irAE) were: 46.1% and 7.1% respectively.

Compared with the use of immune checkpoint inhibitors alone, combined use significantly increases the probability of adverse reactions by more than 2 times, which is also worth noting.

Figure 2 Probability of treatment-related adverse reactions and immunotherapy-related adverse reactions

As shown in the figure above, if immune checkpoint inhibitors are combined with other drugs, the probability of adverse reactions increases significantly. Among them, grade 3-5 adverse reactions are mainly proteinuria, anemia, leukopenia, neutropenia, thrombocytopenia, etc. .

2. Different PD-1s have biases in adverse reactions.

PD-1 is a large class of drugs, but not all PD-1s are exactly the same.

The PD-1 proteins developed by different pharmaceutical companies have different molecular structures and different affinity activities with PD-L1 protein, so the adverse reactions of these PD-1 drugs are also different.

Figure 3 Probability of treatment-related adverse events among different immune checkpoint inhibitors

As shown in the figure above, camrelizumab has a higher probability of developing reactive capillary hemangiomas (58.6% probability). Toripalimab has a 55.6% probability of developing hyperglycemia. Tislelizumab also had a higher probability of causing fever (54.3% probability). Most of these adverse reactions are grade 1-2, and none reach the level of grade 3-5.

In addition, this research report shows that nivolumab (O drug) has the lowest incidence of adverse reactions, with an incidence of 64.1% of treatment-related adverse events of any grade, and an incidence of grade 3-5 treatment-related adverse events. Only 11.8%. The probability of adverse events related to immunotherapy are mild, such as fatigue, and most of these Chinese patients can tolerate it. This is indeed surprising, but the red vertical bar representing O medicine in the picture above is indeed relatively low and not very common.

3. Summary

The researchers remind patients and clinicians to pay attention to the adverse reactions of immune checkpoint inhibitors combined with chemotherapy, especially grade 3-5 adverse reactions, which will affect the patient's quality of life. In some cases, patients also There will be life danger.

Use its advantages and avoid its shortcomings. We hope that most patients can benefit from immune checkpoint inhibitors, and we hope that there will be no adverse reactions.

references

Li Li. et al. Sci Rep. 2020 Sep 23;10(1):15567.

Hey!It’s Time To Get To Know The New Zealand All Blacks (ALL BLACKS)

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all blacks

All (All Blacks), New Zealand's national men's rugby team.

The 42-second super-burning video is worth your 4G data

Rugby is one of New Zealanders' favorite and favorite sports, which can make men, women and children all over the country excited.

In the world of rugby, the All Blacks have to have names.

The All Blacks are famous not only for their famous pre-match Haka (video below) which can overwhelm opponents in terms of momentum, but also because they have long been the world's top men's rugby team.

Since starting to participate in international competitions in 1903, the All Blacks have a winning rate of 77.41% in more than 580 games. It is also the team that has won the most Rugby World Cup titles, winning the championship trophy three times, which has enabled New Zealand to dominate the world rugby rankings for a long time from November 2009 to August 2019. Dominance.

Rugby World Cup Trophy – Webber Ellis Cup

The Rugby World Cup was first held in 1987 and is held every four years. The All Blacks won the championship on behalf of New Zealand in the first and last two tournaments (1987, 2011 and 2015).

All Blacks win Rugby World Cup 2015

The 2019 Rugby World Cup will be held in Japan from September 20th to November 2nd. The current New Zealand men's national rugby team, consisting of 31 people, has been assembled and strives for three consecutive championships.

New Zealand, which is in Group B, will face South Africa, Italy, Namibia and Canada in the group stage.

Please mark the group stage schedule as soon as possible:

This Saturday (September 21), the All Blacks will represent New Zealand in their first group match against South Africa. This will also basically determine the first and second place in Group B.

All Blacks line-up for Saturday's match

The All Blacks are the pride of New Zealanders. On the eve of this Rugby World Cup, Air New Zealand even "changed its name" to "Air All". It not only produced a safety video of the same name, but also offered support online to support the All Blacks.

"Air All" flight safety video

Due to the time difference, this Rugby World Cup event will usually be held at night in New Zealand local time. In order to allow more people to enjoy the fun of rugby, the New Zealand Parliament also passed a bill to enable qualified business establishments (such as bars, cafes and clubs, etc.) to continue operating outside normal business hours so that people can watch the game.

How did rugby develop in New Zealand? How did the All Blacks come about? Let’s find out with the fan editor:

1870

Monro, a young New Zealander studying in London, brought rugby to New Zealand and organized the first game using official rugby rules in Nelson, New Zealand's South Island.

1884

New Zealand's rugby team went abroad for the first time, wearing blue jerseys with golden fern leaves to compete in Australia.

It is said that this is also Haka's first appearance in a New Zealand rugby team game. The haka is not only a traditional Maori war dance, but today its meaning is more diverse. For example, the haka can also be seen in some celebrations to express respect for guests and the importance of the occasion. Many New Zealand sporting teams perform the haka before a game, but the All Blacks' haka is regarded as one of the most feared and revered pre-match rituals in the world.

The All Blacks perform the haka at the 2015 Rugby World Cup

1888

The New Zealand rugby team New traveled to Australia, Egypt and the British Isles to compete. They were the first rugby team to wear black jerseys with a silver fern leaf pattern.

1890

The number of rugby clubs in New Zealand has reached 700.

1891

The proposal for a domestic women's rugby team in New Zealand emerged during the New Zealand Women's Empowerment Movement.

1893

In the second year of the establishment of the New Zealand Rugby Football Union, the black jersey with a silver fern leaf pattern was established as the official jersey. The first New Zealand national team selected by the federation begins the competition.

1905

Team New Zealand came to compete in the Northern Hemisphere and won 34 of 35 games. The haka has since become a pre-match tradition for almost every New Zealand team overseas. This team was the original All Blacks, and they later became known as the All Blacks. Their record has also become a goal that every All Black team strives to surpass.

1905 "" jersey replica

Today's New Zealand All Blacks are a brave, experienced and proud rugby team. Let us look forward to the return of the best team in this year's Rugby World Cup!

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References:

All Blacks fans, please click "Watching"

"Little Alien" Dell G3 Reminds You Of The Classic Three Kingdoms Game

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Games with historical themes have always been loved by players. Among them, games with the Three Kingdoms theme are even more popular among Chinese players. As early as 20 years ago, in an era when PCs were not yet popular, the "Three Kingdoms" series of arcade games became popular in game halls across the country. I don't know how much breakfast money was consumed by friends. Recently, the sales of "Total War: Three Kingdoms" have set off a craze to help the Han Dynasty. Here, Dell G3 takes everyone to reminisce about the classic Three Kingdoms games of those years.

1: "Three Kingdoms" series

"Romance of the Three Kingdoms" is produced by Koei Corporation of Japan. It has been more than 30 years since the first game in the series was released in 1985. Its series of works also spans multiple platforms such as FC and PC. When its first work was released, it caused a huge response in Japan, and won the first place in the Japan BHS Awards and the Most Popular Readers Product Award. What is really praised by mainland Chinese players is the ninth work in the series, namely "Three Kingdoms IX". In this sequel, the game mode dominated by military commanders in the past has been changed. For the first time, a nationwide large map is adopted. Players play and operate as the monarch of a certain force. This generation of classic works still has many MOD versions circulating among players to this day. Among the other works released subsequently, "Romance of the Three Kingdoms 11" is undoubtedly the most amazing. In addition to continuing to use the large map mode, Chinese ink paintings are innovatively used throughout the game. Players also have a stronger sense of history when operating generals on the battlefield.

It is worth mentioning that in addition to the great acclaim of the "Three Kingdoms" series, Honor released a Three Kingdoms-themed game off the series – "Three Kingdoms Heroes". Its representative work "Three Kingdoms: Cao Cao" has become a favorite among a generation of players. Classic memories. As the most successful example of SLG games, in an era when piracy was rampant, its excellent game content was enough to make players indulge in it while staring at the garbled text on the screen. The seemingly incomprehensible text "Fallen B turns into a giant belly" has become a beautiful memory in the hearts of all fans of the Three Kingdoms game.

(Note: The change of valve B into a giant belly is a garbled code from "The Biography of Cao Cao in the Three Kingdoms")

2: "Three Kingdoms" series

"The Romance of the Three Kingdoms" is an action-type ACT stand-alone game adapted from China's "The Romance of the Three Kingdoms" by Taiwan's Yixiang Electronics Company. It was released in 1999. At that time, arcade games dominated the world. Games such as "Ninja Baseball" and "Journey to the West" were the favorites of players. The "Three Kingdoms" series relied on its advanced gameplay and extremely refreshing battles. It stands out among similar games and becomes one of the most classic works in the arcade era.

After the first game became a hit in the market, Yixiang released a sequel in the same year – "Three Kingdoms – The Storm Rises Again". Compared with the previous game, the sequel has a more complex operation mode and richer level settings. The generals who play the game at the same time can form a very gorgeous COMBO to perform multiple combos, thereby obtaining higher scores. Subsequently, Yixiang successively released the ink-style "Three Kingdoms 2" and the 3D style "New Three Kingdoms – Reincarnation of the Seven Stars". In terms of game quality, all sequels are of high quality, but as players gradually grow up, the passionate and simple arcade era is gone forever.

Three: "Three Kingdoms Zhao Yun Biography" series

The "Three Kingdoms Zhao Yun Zhuan" series released by Zhuhai Third Wave Studio may be the most classic Three Kingdoms-themed stand-alone game produced in mainland China. In the game, players play the role of Zhao Yun, a famous general with both wisdom and courage. As the game progresses, Players will experience Zhao Yun's legendary and exciting life. As an ARPG game, it includes character development, magic and nirvana display, equipment smelting system, horse battle system, general duel system and other elements. Its rich gameplay is unparalleled even today. Seems outdated.

In the first-generation game, the story begins with the child Zhao Yun becoming an apprentice and learning skills, and ends with Zhao Yun helping Liu Bei capture Hanzhong. During this period, players played Zhao Yun and experienced various battles, including the Battle of Panhe, the Battle of Bowangpo, and the most famous Battle of Changbanpo. The game performed very well on the battlefield, and the combat system and operating system reached the top quality of domestic games at the time.

After the great success of the first game, Third Wave Studios released the sequel "Three Kingdoms Zhao Yun Zhuan: Across the World" the following year. This game retains all the successful elements of the previous game and makes large-scale enhancements to the weak points of the previous game. The story follows the end of one generation, starting with Liu Bei's capture of Hanzhong and becoming the King of Hanzhong, and then the 700,000-strong army's expedition against Soochow to avenge Guan Yu, and ending with Zhao Yun leading his army into Xuchang to dominate the world. period.

The Three Kingdoms, as a very special period in Chinese history, saw the emergence of famous heroes in an endless stream, coupled with epic battles such as the Battle of Chibi, providing game designers with unlimited creative space. The story of the Three Kingdoms has been adapted into various themes such as operas, novels, and games, and each theme is infinitely exciting. Just like the experience that the Three Kingdoms game brings to players, Dell G3, as a professional e-sports notebook for advanced gamers, can also bring players an excellent gaming experience.

Dell G3, known as the "little alien", is equipped with up to the ninth generation Intel® Core™ i7 processor, which not only handles various MOBA and FPS games perfectly, but also has no problem playing AAA masterpieces on the market.

Dell G3 also has a 144Hz narrow bezel screen with IPS anti-glare function, horn-type super heat dissipation, dual-channel heat dissipation system, equipped with dual heat pipes and dual fans, and a collection of air duct designs. The overall heat dissipation efficiency is higher than that of mainstream game notebooks. It can also The addition of a notebook cooling pad further improves heat dissipation efficiency and also reduces fan noise.

Dell G3 is also equipped with the AWCC Alien Intelligent Control Center, which helps you control various complex functions of the notebook at will. It only needs one setting. Every time you open a game in the future, it will be directly adjusted to the most suitable hardware state for the game. It can be said that A very considerate smart butler.

The Dell G3 fuselage is inspired by the world's first stealth fighter. The sharp-edged cooling grille at the rear resembles the swept wing of a fighter jet. The decorative line on the A side has a sense of mechanical cutting, and the solid-color cover is matched with the center part. The minimalist design style of Dell's LOGO is more intriguing. Let Dell G3 accompany you in the battle and experience the excitement of the Three Kingdoms history!

"Fantasy Westward Journey" PC Version New Expansion Pack Suspense Station Takes You On A Twelve-hour Treasure Hunt Journey

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Beautiful dreams come to the prosperous age, and flowers bloom in Chang'an! Recently, the PC version of "Fantasy Westward Journey" once again released a piece of blockbuster news. A new expansion pack will be released on September 21, bringing a lot of unexpected surprises to everyone. At present, the new information suspense station has been unveiled in the three realms. Here, everyone can participate in the interesting activities prepared by Fantasy Westward Journey in advance, unveil the mystery of the new expansion pack together, and witness the arrival of more exciting content!

Collect treasures and antiquities to unlock surprise content

Game Suspense Station_Suspense Works_Suspense Encyclopedia

During the prosperous period of the Tang Dynasty, all nations came to court. The new expansion pack Suspense Station launched in this Fantasy Westward Journey will take everyone to explore the stories behind twelve rare treasures and start a fantasy treasure collecting journey. During the period from 18:00 on August 30 to 00:00 on September 12, everyone can log in to the NetEase Pass account in the suspense station, select the character that has been created, and join the event. During the event, everyone will get the opportunity to turn the sundial once a day and get a treasure and ancient artifact. When everyone gets these rare treasures, they will be displayed in the treasure collection column of the suspense station for everyone to watch and study.

In order to let everyone know more information about this new expansion pack in advance, each treasure will contain an important clue related to the new expansion pack. Moreover, during the event, after everyone participates in turning the sundial and collects six or more treasures and antiquities, you can also participate in a lottery at the end of the event and have the opportunity to receive point card rewards prepared by Fantasy Westward Journey for everyone. In the suspense station, the list of winners will be announced after the event. Players who participated in the event can come here to watch the winning status of themselves or their friends.

Game Suspense Station_Suspense Encyclopedia_Suspense Works

Start cross-border cooperation and feel the charm of cultural relics

During the event, everyone can not only unlock the latest expansion pack information when collecting treasures, but also listen to the whispers of cultural relics and feel the unique charm they contain. In order to show more precious cultural relics to everyone, Fantasy Westward Journey has once again cooperated with Tang Furong Garden and Xi'an Museum after the last game carnival. Through games, various treasures and antiquities will be brought into the vision of Fantasy players. Let everyone enter the world of cultural relics and understand the historical and cultural connotations behind them.

Suspense Encyclopedia_Suspense Works_Game Suspense Station

Explore the twelve treasures and welcome the new expansion pack! The suspense station of the new expansion pack for the PC version of "Fantasy Westward Journey" has now arrived. It will take everyone into the dream of the prosperous Chang'an and have close contact with various treasures and antiquities. During the event, you can participate in the interesting gameplay of this suspense station with your friends, learn a lot of new expansion pack information in advance, and let the precious cultural relics attract the attention of more fantasy players!

Another non-level + big stunt necklace is born!

Why don't you attack with all your strength?

Suspense Works_Suspense Encyclopedia_Game Suspense Station

Is this the dreamy No. 1 high-spirited unleveled necklace?

The result is truly levelless! ! !

Click here to recharge your batteries (#^.^#)☆